Osteon templates for bone tissue engineering

An osteon template for tissue engineering comprising; a first plurality of vasculogenic filaments 11 comprising a first hydrogel and vessel-forming cells, and a second plurality of osteogenic filaments 12 comprising a second hydrogel and bone-forming cells; wherein the first plurality of vasculogeni...

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Bibliographische Detailangaben
Hauptverfasser:	Kamal Babikeir Eln Mustafa, Ahmad Rashad Saad Mohamed Elsebahy
Format:	Patent
Sprache:	eng
Schlagworte:	ADDITIVE MANUFACTURING TECHNOLOGY ADDITIVE MANUFACTURING, i.e. MANUFACTURING OFTHREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVEAGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING,STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING BANDAGES, DRESSINGS OR ABSORBENT PADS CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF,TUBULAR STRUCTURES OF THE BODY, E.G. STENTS DISINFECTION, STERILISATION, OR DEODORISATION OF AIR FILTERS IMPLANTABLE INTO BLOOD VESSELS FIRST-AID KITS FOMENTATION HUMAN NECESSITIES HYGIENE MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES MEDICAL OR VETERINARY SCIENCE METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES PERFORMING OPERATIONS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROSTHESES TRANSPORTING TREATMENT OR PROTECTION OF EYES OR EARS
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Beschreibung
Zusammenfassung:	An osteon template for tissue engineering comprising; a first plurality of vasculogenic filaments 11 comprising a first hydrogel and vessel-forming cells, and a second plurality of osteogenic filaments 12 comprising a second hydrogel and bone-forming cells; wherein the first plurality of vasculogenic filaments 11 is arranged alternately with the second plurality of osteogenic filaments 12 in a concentric arrangement 10. Preferably the osteon template further comprises a central void 13 at the centre of the concentric arrangement 10, and there may be at least one radial channel 14 emanating from the centre 15 of the concentric arrangement 10 to interrupt the first 11 and second 12 pluralities of filaments. In one embodiment the concentric arrangement 10 forms a first filament layer, wherein one or more further filament layers 10 are stacked to form a three-dimensional osteon template (110, fig. 5). The osteon template is made using additive manufacturing.