Means for treating sexually-transmitted infectious diseases

The present invention relates to the treatment of urogenital infectious diseases caused by pathogenic microorganisms. A pharmaceutical composition or compositions contain 3,3'-diindolylmethane (DIM) or a derivative thereof, alone or in combination with epigallocatechin-3-gallate (EGCG), and additionally optionally contain one or more antimicrobial agents for use in treating or preventing an infectious disease of the urogenital system caused by one or a plurality of microorganisms, the infectious disease of the urogenital system subject to treatment or prevention being able to result from, for instance, a microbial (i.e., bacterial, viral or fungal) infection. The methods and compositions of the present invention are especially useful for treating or preventing infectious diseases caused by such bacterial infections as, for instance, Ureaplasma urealyticum, mycoplasma species such as M hominis, N. gonorrhea, and T. pallidum, species of Gardnerella, species of Chlamydia bacteria, such as Chlamydia trachomatis, viral infections such as Herpes Simplex, papillomavirus, cytomegalovirus, HIV, a hepatitis virus such as hepatitis B, or fungal infections such as Candida albicans. The treatment or prevention of any infection may be directed, for instance, at the vagina, cervix and/or uterus.