Open-Top Microfluidic Device With Structural Anchors

A microfluidic device is contemplated comprising an open-top cavity with structural anchors on the vertical wall surfaces that serve to prevent gel shrinkage-induced delamination, a porous membrane (optionally stretchable) positioned in the middle over a microfluidic channel(s). The device is partic...

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Bibliographische Detailangaben
Hauptverfasser: Daniel Levner, Justin K Nguyen, Christopher David Hinojosa, Norman Wen, Carol Lucchesi, Lina Williamson, Jordan Kerns, Geraldine Hamilton, Antonio Varone, Katia Karalis
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:A microfluidic device is contemplated comprising an open-top cavity with structural anchors on the vertical wall surfaces that serve to prevent gel shrinkage-induced delamination, a porous membrane (optionally stretchable) positioned in the middle over a microfluidic channel(s). The device is particularly suited to the growth of cells mimicking dermal layers.