Substituted catechols as inhibitors of IL-4 and IL-5 for the treatment bronchial asthma

The present invention relates to compounds of general formula 1 for the treatment of bronchial asthma by inhibition of IL-4 or IL-5 pathway inhibition. The present invention also relates to the use of compound of general formula 1 for the treatment of bronchial by inhibition of IL-4 or IL-5 pathway....

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Hauptverfasser:	JAYARAMAN VINAYAGAM, BHOLANATH PAUL, NAHID ALI, SUSHOVAN CHOWDHURY, BALARAM GHOSH, BIKAS CHANDRA PAL, INDRANI CHOUDHURY MUKHERJEE, PRADYOT BHATTACHARYA, ARJUN RAM, JAYASHREE BAGCHI CHAKRABORTY, ULAGANATHAN MABALIRAJAN, SANJIT KUMAR MAHATO, ROMA SINHA, ANIRBAN MANNA, ARUN BANDOPADHYAY, DEBA PRASAD JANA, SANTU BANDYOPADHYAY, ADITYA KONAR, JAYDEEP CHAUDHURI, SIDDHARTHA ROY, PARASURAMAN JAISANKAR
Format:	Patent
Sprache:	eng
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to compounds of general formula 1 for the treatment of bronchial asthma by inhibition of IL-4 or IL-5 pathway inhibition. The present invention also relates to the use of compound of general formula 1 for the treatment of bronchial by inhibition of IL-4 or IL-5 pathway. The present invention also relates to the method of treating asthma by inhibition of IL-4 or IL-5 pathway by administration of compound or said composition through oral, intranasal, route or by inhalation to a mammal in need thereof. Compound of general formula 1 may be used for reducing perivascular and peribronchial inflammation.