Novel crystalline forms of 6alpha, 9alpha-difluoro-11beta hydroxy-16al-pha-methyl-3-oxo-17alpha-propionyloxy-androsta-1, 4-diene-17beta-carbyoxylic acid

Novel crystalline forms of 6alpha, 9alpha-difluoro-11beta hydroxy-16al-pha-methyl-3-oxo-17alpha-propionyloxy-androsta-1, 4-diene-17beta-carbyoxylic acid

Novel crystalline forms II, III, IV, V, VI, VII and VIII of 6alpha,9 alpha -difluoro-11beta-hydroxy-16alpha-methyl-3-oxo-17alpha-propionyloxyandrosta-1,4-diene-17beta-carboxylic acid, a chemical intermediate useful in the preparation of fluticasone propionate, and novel methods of making these forms...

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Bibliographische Detailangaben
Hauptverfasser: ITAI ADIN, CARMEN IUSTAIN, YURI FUTERMAN
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
STEROIDS
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Zusammenfassung:Novel crystalline forms II, III, IV, V, VI, VII and VIII of 6alpha,9 alpha -difluoro-11beta-hydroxy-16alpha-methyl-3-oxo-17alpha-propionyloxyandrosta-1,4-diene-17beta-carboxylic acid, a chemical intermediate useful in the preparation of fluticasone propionate, and novel methods of making these forms, substantially free of water, are disclosed.