Antagonisation of anticoagulants

Antagonisation of anticoagulants

The present invention relates to new peptides of the general formula (I) R -(B )m-(B )n-Tyr-(B )o(-B )p-Asnq-Asnr-Tyrs-Leut-B -(Pro)u-Phe-Abu-B -(B )v-R ```(I) wherein R represents hydrogen or (C1-C8)-acyl, R represents OH, O-(C1-C8)-alkyl, NH2 or Ala-Asp-Pro-OH, B to B represent, independent of one...

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Bibliographische Detailangaben
Hauptverfasser: RETO SCHONI, RETO STOCKLIN, ANNA PERCHUC, BEATRICE BUHLER, MARIANNE WILMER, LAURE MENIN, MARC HEIDL
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:The present invention relates to new peptides of the general formula (I) R -(B )m-(B )n-Tyr-(B )o(-B )p-Asnq-Asnr-Tyrs-Leut-B -(Pro)u-Phe-Abu-B -(B )v-R ```(I) wherein R represents hydrogen or (C1-C8)-acyl, R represents OH, O-(C1-C8)-alkyl, NH2 or Ala-Asp-Pro-OH, B to B represent, independent of one another, a basic amino acid, such as arginine, homoarginine, lysine, ornithine, 2,4-diaminobutyric acid or 2,3-diaminopropionic acid m,n,o,p,q,r,s,t,u,v represent, independent of one another, zero or 1, and their salts as well as pharmaceutical compositions characterized by containing a myotoxic phospholipase A2 (PLA2) or an other snake venom containing the common peptide sequence KKYKNNYLKPFCKK. The peptides and the pharmaceutical compositions can be used for the antagonisation of heparins, LMWH, pentasaccharide, danaparoid or other related anticoagulants. Reagent kits for in vitro analysis of blood or blood components are also described.