Method and apparatus for sensing a time varying current passing through an ion channel

A capacitive sensing system (2, 2', 2'') is used to measure a timevarying ion current through a channel (50), such as an ion channel or protein pore. Such a capacitive system (2, 2', 2'') does not suffer problems of electrode corrosion and, when used with methods to con...

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Bibliographische Detailangaben
Hauptverfasser: ANDREW D HIBBS, REGINA E DUGAN
Format: Patent
Sprache:eng
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Zusammenfassung:A capacitive sensing system (2, 2', 2'') is used to measure a timevarying ion current through a channel (50), such as an ion channel or protein pore. Such a capacitive system (2, 2', 2'') does not suffer problems of electrode corrosion and, when used with methods to control a build up of ion concentration, allows the use of measurement volumes (10, 20) around the channel (50) with dimensions on a scale of nanometers.