Antiinflammatory heterocyclic sulphones

Antiinflammatory heterocyclic sulphones

Compounds of the formula are useful in the treatment of inflammatory processes, where Het represents a C-bound heterocycle, and A represents an optional substituent on the heterocycle, m being from 0 to 3. D represents an optionally substituted (C 1 -C 4 )-alkandiyl, E represents CH=CH, CH=N or N=CH...

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Hauptverfasser: CARSTEN SCHMECK, ELISABETH RANK, RUDI GRUETZMANN, BEATRIX STELTE LUDWIG, KLAUS URBAHNS, JOACHIM SCHUHMACHER, DIETER LANG, MICHAEL BRANDS, DR BERND KALTHOF, MARTIN RAABE, JOERG KELDENICH, ULLRICH MUELLER, JOSEF PERNERSTORFER, SIEGFRIED ZAISS, HARTMUT SCHIROK
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:Compounds of the formula are useful in the treatment of inflammatory processes, where Het represents a C-bound heterocycle, and A represents an optional substituent on the heterocycle, m being from 0 to 3. D represents an optionally substituted (C 1 -C 4 )-alkandiyl, E represents CH=CH, CH=N or N=CH, and G represents a group of the formula wherein R2 represents H or (C 1 -C 6 )-alkyl, R1, R3 and R4 are groups selected from hydrogen, halogen, hydroxy, nitro, trifluoromethyl, trifluoromethoxy, hydroxymethyl, (C 1 -C 6 )-alkoxy, (C 1 -C 6 )-alkoxycarbonyl, (C 6 -C 10 )-aryloxy or (C 1 -C 6 )-alkyl, and R5 is optionally substituted (C 6 -C 10 )-aryl, (C 5 -C 10 )-heteroaryl, (C 3 -C 8 )-cycloalkyl or (C 1 -C 7 )-alkyl.