Biopolymer arrays and their fabrication

An addressable array (12, see Fig. 1) of biopolymers is fabricated on a substrate 10 using biomonomers 44 having a first linking group which must be activated for linking to a substrate bound moiety. A solid activator composition 42 is formed on a region of the substrate carrying the moiety, via dro...

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Bibliographische Detailangaben
1. Verfasser:	MICHEL G M PERBOST
Format:	Patent
Sprache:	eng
Schlagworte:	APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY APPARATUS THEREFOR BEER BIOCHEMISTRY CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY CHEMISTRY COMBINATORIAL CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA DERIVATIVES THEREOF ENZYMOLOGY GENERAL METHODS OF ORGANIC CHEMISTRY INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL PHYSICS PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS SUGARS TESTING THEIR RELEVANT APPARATUS TRANSPORTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	An addressable array (12, see Fig. 1) of biopolymers is fabricated on a substrate 10 using biomonomers 44 having a first linking group which must be activated for linking to a substrate bound moiety. A solid activator composition 42 is formed on a region of the substrate carrying the moiety, via droplet 40. A biomonomer containing fluid composition 44 is deposited on the region so that the solid activator activates the first linking group and the biomonomer links to the substrate bound moiety. These steps may be repeated, wherein a biomonomer deposited and linked to the substrate bound moiety in one cycle is the substrate bound moiety for the next cycle, so as to form the biopolymer. Apparatus and a computer program product are also used. The arrays may be used to screen for the presence of a target polynucleotide in a sample, by exposing the sample to the array and observing the resulting binding pattern.