SYNTHESIZING CRBAPENEM INTERMEDIATES
A process of synthesizing a compound of formula 1: wherein P and P' independently represent H or a protecting group, R1 represents H or C1-4alkyl, and Hal represents a halogen, comprising: reacting a compound of formula 2: wherein P, P', and R1 are defined above, with R2OH, wherein R2 is C...
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| creator | JOHN Y.L. CHUNG JOHNNIE L LEAZER NOBUYOSHI YASUDA |
| description | A process of synthesizing a compound of formula 1: wherein P and P' independently represent H or a protecting group, R1 represents H or C1-4alkyl, and Hal represents a halogen, comprising: reacting a compound of formula 2: wherein P, P', and R1 are defined above, with R2OH, wherein R2 is C1-4 alkyl, C5-10 aryl or C5-10 heteroaryl in the presence of an acid catalyst or carbodiimide reagent to produce a compound of formula 3: wherein P, P', and R1 are defined above; and reacting a compound of formula 3 in the presence of a base and a haloalkylating agent to produce a compound of formula I. |
| format | Patent |
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CHUNG ; JOHNNIE L LEAZER ; NOBUYOSHI YASUDA</creatorcontrib><description>A process of synthesizing a compound of formula 1: wherein P and P' independently represent H or a protecting group, R1 represents H or C1-4alkyl, and Hal represents a halogen, comprising: reacting a compound of formula 2: wherein P, P', and R1 are defined above, with R2OH, wherein R2 is C1-4 alkyl, C5-10 aryl or C5-10 heteroaryl in the presence of an acid catalyst or carbodiimide reagent to produce a compound of formula 3: wherein P, P', and R1 are defined above; and reacting a compound of formula 3 in the presence of a base and a haloalkylating agent to produce a compound of formula I.</description><edition>6</edition><language>eng</language><subject>CHEMISTRY ; CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION ORPROCESSING OF GOODS ; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC ; GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; ORGANIC CHEMISTRY ; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS ; TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE</subject><creationdate>1999</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19990303&DB=EPODOC&CC=GB&NR=2328687A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19990303&DB=EPODOC&CC=GB&NR=2328687A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>JOHN Y.L. 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CHUNG ; JOHNNIE L LEAZER ; NOBUYOSHI YASUDA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_GB2328687A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>1999</creationdate><topic>CHEMISTRY</topic><topic>CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION ORPROCESSING OF GOODS</topic><topic>GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC</topic><topic>GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS</topic><topic>TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE</topic><toplevel>online_resources</toplevel><creatorcontrib>JOHN Y.L. CHUNG</creatorcontrib><creatorcontrib>JOHNNIE L LEAZER</creatorcontrib><creatorcontrib>NOBUYOSHI YASUDA</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>JOHN Y.L. CHUNG</au><au>JOHNNIE L LEAZER</au><au>NOBUYOSHI YASUDA</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>SYNTHESIZING CRBAPENEM INTERMEDIATES</title><date>1999-03-03</date><risdate>1999</risdate><abstract>A process of synthesizing a compound of formula 1: wherein P and P' independently represent H or a protecting group, R1 represents H or C1-4alkyl, and Hal represents a halogen, comprising: reacting a compound of formula 2: wherein P, P', and R1 are defined above, with R2OH, wherein R2 is C1-4 alkyl, C5-10 aryl or C5-10 heteroaryl in the presence of an acid catalyst or carbodiimide reagent to produce a compound of formula 3: wherein P, P', and R1 are defined above; and reacting a compound of formula 3 in the presence of a base and a haloalkylating agent to produce a compound of formula I.</abstract><edition>6</edition><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION ORPROCESSING OF GOODS GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE |
| title | SYNTHESIZING CRBAPENEM INTERMEDIATES |
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