SYNTHESIZING CRBAPENEM INTERMEDIATES

A process of synthesizing a compound of formula 1: wherein P and P' independently represent H or a protecting group, R1 represents H or C1-4alkyl, and Hal represents a halogen, comprising: reacting a compound of formula 2: wherein P, P', and R1 are defined above, with R2OH, wherein R2 is C...

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Bibliographische Detailangaben
Hauptverfasser:	JOHN Y.L. CHUNG, JOHNNIE L LEAZER, NOBUYOSHI YASUDA
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION ORPROCESSING OF GOODS GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE
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Beschreibung
Zusammenfassung:	A process of synthesizing a compound of formula 1: wherein P and P' independently represent H or a protecting group, R1 represents H or C1-4alkyl, and Hal represents a halogen, comprising: reacting a compound of formula 2: wherein P, P', and R1 are defined above, with R2OH, wherein R2 is C1-4 alkyl, C5-10 aryl or C5-10 heteroaryl in the presence of an acid catalyst or carbodiimide reagent to produce a compound of formula 3: wherein P, P', and R1 are defined above; and reacting a compound of formula 3 in the presence of a base and a haloalkylating agent to produce a compound of formula I.