Compounds comprising a target cell-specific portion and a further portion

A compound comprising a target cell-specific portion and a directly or indirectly cytotoxic portion, characterised in that the target cell-specific portion recognises the target cell with high avidity. The cytotoxic portions of the compound may be a subunit of an oligomer, may contain a binding site...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	AGAMEMNON ANTONIOU EPENETOS, MAHENDRA DEONARAIN, ROBERT ANTHONY SPOONER
Format:	Patent
Sprache:	eng
Schlagworte:	HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MANUFACTURE OR TREATMENT OF NANOSTRUCTURES MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES MEASURING MEDICAL OR VETERINARY SCIENCE NANOTECHNOLOGY PERFORMING OPERATIONS PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES TESTING TRANSPORTING
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Beschreibung
Zusammenfassung:	A compound comprising a target cell-specific portion and a directly or indirectly cytotoxic portion, characterised in that the target cell-specific portion recognises the target cell with high avidity. The cytotoxic portions of the compound may be a subunit of an oligomer, may contain a binding site for a small molecule, may be streptavidin, may be a dimeric ribonuclease or may be DNAso-I. The target cell-specific portion may comprise two or more binding sites for the target cell, may be an antibody or fragment thereof, or may be an ScFv. A compound suitable for cell agglutination, particularly haemagglutination. A compound comprising a mediator portion and a directly or indirectly cytotoxic portion wherein the mediator portion recognises a target cell-specific molecule and provides a means of indirect targeting.