1-[2-(substituted vinyl)]-3,4-dihydro-5H-2,3-benzodiazepine derivatives

1-[2-(substituted vinyl)]-3,4-dihydro-5H-2,3-benzodiazepine derivatives

New 1-[2-(substituted vinyl)]-3,4-dihidro-5 H -2,3-benzodiazepine derivatives correspond to the general formula (I), wherein R represents hydrogen or C 1-4 alkanoyl, R 1 stands for phenyl optionally carrying 1-3 identical or different substituent(s) selected from halogen, nitro, amino, C 1-4 alkylam...

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Hauptverfasser: GYOERGYNE MATE, FERENC ANDRASI, IMRE MORAVCSIK, ESZTER SZENTKUTI, PAL VAGO, EDIT HORVATH, GYOERGY SOMOGYI, ANNA BAKONYI, GABOR ZOLYOMI, ERZSEBET BIRKAS FAIGLNE, TAMAS HAMORI, PETER BOTKA, GABOR GIGLER, JENO KOROSI, JOSZEF REITER, PAL BERZSENYI, KATALIN HORVATH, ISTVAN GYERTYAN
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:New 1-[2-(substituted vinyl)]-3,4-dihidro-5 H -2,3-benzodiazepine derivatives correspond to the general formula (I), wherein R represents hydrogen or C 1-4 alkanoyl, R 1 stands for phenyl optionally carrying 1-3 identical or different substituent(s) selected from halogen, nitro, amino, C 1-4 alkylamino, di(C 1-4 alkyl)-amino, C 1-4 alkanoylamino, C 1-4 alkyl, C 1-4 alkoxy, methylenedioxy and hydroxy; or naphthyl optionally carrying a substituent selected hydroxy, C 1-4 alkyl and C 1-4 alkoxy; R 2 stands for hydrogen or C 1-4 alkyl; R 3 and R 4 are independently C 1-4 alkyl, or R 3 and R 4 together form methylene. The new compounds affect the central nervous system and can be used to advantage in the therapy.