7-Diazo-beta-lactam derivatives

7-Diazo-beta-lactam derivatives

Novel 7-diazo-1,1-dioxo-cephem-4-ketones are converted to 1,1-dioxo-cephem-4-ketones substituted at C-7 which are potent protease inhibitors, in particular human leukocyte elastase (HLE) inhibitors.

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Bibliographische Detailangaben
Hauptverfasser: ETTORE PERRONE, MARCO ALPEGIANI, PIERLUIGI BISSOLINO
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:Novel 7-diazo-1,1-dioxo-cephem-4-ketones are converted to 1,1-dioxo-cephem-4-ketones substituted at C-7 which are potent protease inhibitors, in particular human leukocyte elastase (HLE) inhibitors.