Bioconversion products of 27-hydroxy avermectin

Both isomers of 27-hydroxy avermectin aglycones represented by compound (I> wherein the broken line at the 22, 23-position indicates a single or double bond, R1 is present only when the broken line is a single bond, R1 is hydrogen, and the wavy line at the 27-position represents the A and B isome...

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Bibliographische Detailangaben
Hauptverfasser:	PATRICK J DOHERTY, BYRON H ARISON, MARVIN D SCHULMAN
Format:	Patent
Sprache:	eng
Schlagworte:	AGRICULTURE ANIMAL HUSBANDRY BEER BIOCHEMISTRY BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES CHEMISTRY DERIVATIVES THEREOF ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE FISHING FORESTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HUNTING METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PEST REPELLANTS OR ATTRACTANTS PLANT GROWTH REGULATORS PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF SPIRITS SUGARS TRAPPING VINEGAR WINE
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Beschreibung
Zusammenfassung:	Both isomers of 27-hydroxy avermectin aglycones represented by compound (I> wherein the broken line at the 22, 23-position indicates a single or double bond, R1 is present only when the broken line is a single bond, R1 is hydrogen, and the wavy line at the 27-position represents the A and B isomers, are produced by cultivating a strain of the microorganism S. erythrea in a nutrient medium containing assimilable sources of nitrogen and carbon and an avermectin aglycone substrate under aerobic conditions until a substantial amount of compound (I) is produced and isolating the compound (I) so produced. Compound (I) may be converted to other avermectin derivatives, e.g. The compounds and the intermediates used to make them are highly potent antiparasitic, insecticidal and anthelmintic avermectin agents.