GB2183647

Water soluble prodrugs of rapamycin are disclosed which are useful as components in injectable pharmaceutical formulations for the treatment of tumors in mammals. Said prodrugs are rapamycin derivatives or salts thereof mono substituted at position 28 or disubstituted at position 28 or and 43 by acylamino substituent of formulawherein m is an integer from 1 to 3 and R1 and R2 are each hydrogen or an alkyl radical having from 1 to 3 carbon atoms or R1 and R2 together with the nitrogen atom to which they are attached form a saturated heterocyclic ring having 4-5 carbon atoms.