PROCESS FOR THE PREPARATION OF 2-BROMO-A-ERGOCRYPTINE

The invention relates to a novel process for the preparation of 2-bromo- alpha -ergocryptine and its acid addition salt by brominating alpha -ergocryptine in such a way that the bromination is carried out at room temperature by using a dimethylsulphoxide-hydrogen bromide mixture containing no more 0...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	GABOR MEGYERI, TIBOR KEVE, JANOS GALAMBOS, LAJOS KOVACS JR, BELA STEFKO, ERIK BOGSCH, FERENC TRISCHLER
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The invention relates to a novel process for the preparation of 2-bromo- alpha -ergocryptine and its acid addition salt by brominating alpha -ergocryptine in such a way that the bromination is carried out at room temperature by using a dimethylsulphoxide-hydrogen bromide mixture containing no more 0.02% of water and, if desired, converting the thus-obtained 2-bromo- alpha -ergocryptine to an acid addition salt in a known manner.