APOVINCAMINIC ACID ESTER DERIVATIVES

APOVINCAMINIC ACID ESTER DERIVATIVES

A process is disclosed for the preparation of racemic cis or trans apovincaminic acid esters of the formula (I) (I) and the corresponding optically active derivatives of the formulae (Ia) (Ia) and/or (Ib) (Ib) and/or (Ic) (Ic) and/or (Id) (Id) wherein R1 and R2 are identical or different alkyl group...

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Hauptverfasser: DR ANDRAS NEMES, DR CSABA SZANTAY, DR LASZLO CZIBULA, DR MARIA FARKAS, DR LAJOS SZABO, DR GYORGY KALAUS, DR JANOS KREIDL, GYORGY VISKY
Format: Patent
Sprache:eng
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APPARATUS THEREFOR
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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creator DR ANDRAS NEMES
DR CSABA SZANTAY
DR LASZLO CZIBULA
DR MARIA FARKAS
DR LAJOS SZABO
DR GYORGY KALAUS
DR JANOS KREIDL
GYORGY VISKY
description A process is disclosed for the preparation of racemic cis or trans apovincaminic acid esters of the formula (I) (I) and the corresponding optically active derivatives of the formulae (Ia) (Ia) and/or (Ib) (Ib) and/or (Ic) (Ic) and/or (Id) (Id) wherein R1 and R2 are identical or different alkyl groups having 1 to 6 carbon atoms. Apovincaminic acid alkyl esters are well-known vasodilating compounds.
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subjects APPARATUS THEREFOR
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
title APOVINCAMINIC ACID ESTER DERIVATIVES
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