APOVINCAMINIC ACID ESTER DERIVATIVES

APOVINCAMINIC ACID ESTER DERIVATIVES

A process is disclosed for the preparation of racemic cis or trans apovincaminic acid esters of the formula (I) (I) and the corresponding optically active derivatives of the formulae (Ia) (Ia) and/or (Ib) (Ib) and/or (Ic) (Ic) and/or (Id) (Id) wherein R1 and R2 are identical or different alkyl group...

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Bibliographische Detailangaben
Hauptverfasser: DR ANDRAS NEMES, DR CSABA SZANTAY, DR LASZLO CZIBULA, DR MARIA FARKAS, DR LAJOS SZABO, DR GYORGY KALAUS, DR JANOS KREIDL, GYORGY VISKY
Format: Patent
Sprache:eng
Schlagworte:
APPARATUS THEREFOR
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:A process is disclosed for the preparation of racemic cis or trans apovincaminic acid esters of the formula (I) (I) and the corresponding optically active derivatives of the formulae (Ia) (Ia) and/or (Ib) (Ib) and/or (Ic) (Ic) and/or (Id) (Id) wherein R1 and R2 are identical or different alkyl groups having 1 to 6 carbon atoms. Apovincaminic acid alkyl esters are well-known vasodilating compounds.