A COMPOUND WITH ANALGESIC AND ANTI-INFLAMMATORY ACTIVITY A PROCESS FOR PRODUCING SAME AND RELATED PHARMACEUTICAL COMPOSITIONS

A COMPOUND WITH ANALGESIC AND ANTI-INFLAMMATORY ACTIVITY A PROCESS FOR PRODUCING SAME AND RELATED PHARMACEUTICAL COMPOSITIONS

N-(2-pyridyl)-[1,4-dimethyl-5-(4- chlorobenzoyl)]-2-pyrrolacetamide, of formula I: can be prepared by reacting an ester, preferably the cyanomethyl ester, of 1,4-dimethyl-5-(4-chlorobenzoyl)-2- pyrrolacetic acid with a molar excess of 2-aminopyridine at from 70 to 200 DEG C, thereby producing a comp...

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Bibliographische Detailangaben
1. Verfasser: GIANGIACOMO MASSAROLI
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:N-(2-pyridyl)-[1,4-dimethyl-5-(4- chlorobenzoyl)]-2-pyrrolacetamide, of formula I: can be prepared by reacting an ester, preferably the cyanomethyl ester, of 1,4-dimethyl-5-(4-chlorobenzoyl)-2- pyrrolacetic acid with a molar excess of 2-aminopyridine at from 70 to 200 DEG C, thereby producing a compound possessing analgesic and anti-inflammatory activity and capable of formulation into pharmaceutical preparations useful in the treatment of acute and chronic pain.