HUMAN LEUCOCYTE PEPSIN LIKE ENZYME

HUMAN LEUCOCYTE PEPSIN LIKE ENZYME

Purified enzyme (I), analogous to human leucocyte pepsin, has the following properties (1) mol. wt. 35000-41000; (2) isoelectric point pH 2.5-3.5; (3) max. absorbence at 278 nm.; (4) positive ninhydrin reaction; (5) easily soluble in water but insoluble in ether and chloroform, and (6) is a white po...

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Bibliographische Detailangaben
Hauptverfasser: YASUO SUSUKI, HARUO OHNISHI, HIROSHI KOSUZUME, EI MOCHIDA
Format: Patent
Sprache:eng
Schlagworte:
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Zusammenfassung:Purified enzyme (I), analogous to human leucocyte pepsin, has the following properties (1) mol. wt. 35000-41000; (2) isoelectric point pH 2.5-3.5; (3) max. absorbence at 278 nm.; (4) positive ninhydrin reaction; (5) easily soluble in water but insoluble in ether and chloroform, and (6) is a white powder with antiallergic and antitumour activities and activity against immuno-complex disorders. (I) administered orally, rectally or by inhalation, pref. at 1-1000, esp. 5-500, mg. per day. (I) suppresses prodn. of IgE so is useful for treating e.g. bronchial asthma, urticaria, dermatitis, etc. It also inhibits immuno-complex disorders such as thyroiditis and nephritis and has activity against e.g. L1210 and P388 leukaemia and MX-1 human breast cancer. Since (I) is of human origin, there are no serious risks of anaphylactic reactions and in mice, parenteral doses of 2 g. (I) per kg. caused no toxic symptoms.