THIENOBENZOTHIEPINS

THIENOBENZOTHIEPINS

4-(1-Methyl-4-piperidylidene)- 4,9-dihydrothieno(2,3-c)-2- benzothiepin of formula I and its hydrogen (+) tartrate (a novel salt) are prepared by the reaction of thieno(2,3-c)-2-benzothiepin-4(9H)- one with 1-methyl-4- piperidylmagnesium chloride in tetrahydrofuran and subsequent acid- catalysed deh...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: JAN METYS, MIROSLAV RAJSNER, ZDENEK POLIVKA, MIROSLAV PROTIVA
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:4-(1-Methyl-4-piperidylidene)- 4,9-dihydrothieno(2,3-c)-2- benzothiepin of formula I and its hydrogen (+) tartrate (a novel salt) are prepared by the reaction of thieno(2,3-c)-2-benzothiepin-4(9H)- one with 1-methyl-4- piperidylmagnesium chloride in tetrahydrofuran and subsequent acid- catalysed dehydration of the resulting 4- (1-methyl-4-piperidyl)-4,9- dihydrothieno(2,3-c)-2-benzothiepin- 4-ol after removal of the simultaneously formed 7-(1-methyl-4- piperidyl)thieno(2,3-c)-2-benzothiepin -4(9H)-one. Compound I and especially its hydrogen (+) tartrate possess high antihistamine, antiserotonin, antireserpine and anticataleptic activity and are expected to find use in the therapy of migraine.