ASPIRIN FORMULATIONS

1287475 Aspirin preparations ASPRONICHOLAS Ltd 25 Nov 1970 [28 Nov 1969] 58203/69 Heading A5B Free-flowing readily-wettable aspirin particles comprise a core of aspirin encompassed by a water - soluble pharmaceutically - acceptable coating having a m.p. of at least 105‹C which coating comprises amin...

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Bibliographische Detailangaben
Hauptverfasser: GRAHAM ARTHUR BONCEY, JAMES RAE HENDERSON, MAURICE JOHN HEDGE
Format: Patent
Sprache:eng
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Zusammenfassung:1287475 Aspirin preparations ASPRONICHOLAS Ltd 25 Nov 1970 [28 Nov 1969] 58203/69 Heading A5B Free-flowing readily-wettable aspirin particles comprise a core of aspirin encompassed by a water - soluble pharmaceutically - acceptable coating having a m.p. of at least 105‹C which coating comprises amino-acid, a sugar or sugar alcohol. They may be produced by suspending aspirin particles in an aqueous solution of the coating material and spray-drying the suspension. Coating materials specified are mannitol, sorbitol, inositol, sucrose, lactose, an arabino-galactan polymeric sugar, glycine and methionine. The preparation may also include a wetting agent, a water-soluble filmforming agent, an effervescent couple and/or a sweetener.