NEW PHENOTHIAZINE DERIVATIVES, PROCESSES FOR THE PRODUCTION THEREOF, AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME

1,202,336. Phenothiazines. ASTA-WERKE A.G. CHEMISCHE FABRIK. 19 Nov., 1968 [29 Nov., 1967]. No. 54844/68. Heading C2C. Compounds (I) and their salts where A is a straight or branched chain 2-4C alkylene residue, R is H, halogen, 1-4C-alkyl optionally halogen substituted, 1-40-alkylmercapto, 1-4 C-alkoxy, 1-4 C-alkylsulphonyl or 1-40-alkanoyl or CN, X is -CH= or -N=, Y 1 , Y 2 , Y 3 are H or 1-4C-alkyl, Z 1 is or >N-R1, R1 is Me or Et, and m and n are each 2 or 3 except compounds wherein A is -(CH 2 ) 3 -, R is Cl, X is -CH=, Y 1 , Y 2 , Y 3 are H m is 2, n is 2 or 3, and Z is > NMe or > NEt, are prepared by reacting (a) a phenothiazine (II) with a compound (III) where Z 2 is the residue of a reactive ester or (b) a compound (IV) with a compound (V) or (c) a compound (VI) with a compound (VII) Pharmaceutical compositions comprise the compounds (I) with an inert carrier. The compositions which may be in a form suitable enteral and parenteral administration are useful as sedatives.