Substituted Uracils

1,168,391. Substituted levacils. INSTITUT ORGANNICHESKOGO SINTEZA AN LATVIISKOI SSR. 8 Jan., 1968, No. 991/68. Heading C2C. Novel compounds of the formula and alkali metal salts thereof, in which R 1 is an alpha-furanidyl or alpha-pyramidyl group and R is a trifluoromethyl group or a fluorine or chlorine atom or (when R 1 is an alpha-furamidyl group) a methyl group or a bromine, or iodine atom, are produced by reacting a mercury or bis-trimethylsilyl derivative of an appropriate 5-substituted uracil with 2-chlorofuranidine or 2-chloropyramidine at a temperature of from - 60‹ to + 40‹ C. The compound obtained can be converted into an alakli metal salt thereof by reaction with an aqueous solution of alkali, an aqueous solution of an alkali metal salt of a weak acid or an alcoholic solution of an alkali metal alcoholate. A pharmaceutical composition comprising the above compounds and their alkali metal salts with a pharmaceutical carrier or diluent has antimetabolite activity and can be effectively used as anti-tumour and anti-virus agents and is administered by injection.