A new salt and a new process for the recovery of kanamycin

The invention relates to kanamycin lauryl sulphate. Kanamycin lauryl sulphate is obtained by the addition of sodium lauryl sulphate to a clarified culture broth of Streptomyces Kanamyceticus at pH 2 to 6 and especially 3.8. Kanamycin sulphate may be obtained from kanamycin lauryl sulphate by dissolv...

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Bibliographische Detailangaben
Hauptverfasser:	SARCINA ARISTIDE, FABRIZIO GERARDO
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY DERIVATIVES THEREOF ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY SPIRITS SUGARS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention relates to kanamycin lauryl sulphate. Kanamycin lauryl sulphate is obtained by the addition of sodium lauryl sulphate to a clarified culture broth of Streptomyces Kanamyceticus at pH 2 to 6 and especially 3.8. Kanamycin sulphate may be obtained from kanamycin lauryl sulphate by dissolving in water, adjusting to pH 9 to 11 by means of an organic or inorganic base, precipitating the lauryl sulphuric anion with Ba(OH)2, separating the precipitate and creating the residual aqueous solution with activated charcoal, adjusting to pH 8.0 with H2SO4 and finally adding methanol or acetone. Alternatively, the kanamycin lauryl sulphate may be dissolved in methanol, the pH adjusted to 8 with ammonia and lauryl sulphate precipitated by addition of sulphuric acid.