SYNTHESE DIRECTE DE SELS QUATERNAIRES DE PHENANTHRIDINIUM

Process for the preparation of phenanthridinium quaternary salts (I) comprises reacting a halo-aromatic compound (II) with a phenyl boronic derivative (III) in a basic medium, in the presence of a palladium catalyst. Process for the preparation of phenanthridinium quaternary salts of formula (I) comprises reacting a halo-aromatic compound of formula (II) with a phenyl boronic derivative of formula (III) in a basic medium, in the presence of a palladium catalyst. R , R = an electro-attractor group having an electronegativity at last equal to that of nitro; R = a non-chemically labile group; R = aryl or 5-12C heteroaryl, which my be condensed and may have one or more hetero atoms; X = a halide or hydrogen sulfate anion or a base joined to a mineral acid; X = halogen; R = H; R+R = a group of formula (i); n, n' = 0-4; R , R = H or 1-5C alkyl. Independent claims are also included for: (1) intermediates of formula (VI); and (2) the preparation of (VI). X1 = halogen.