Ribose-substituted aromatic amide antibiotics, active against anaerobic gram positive bacteria such as staphylococci, streptococci, pneumococci, enterococci, and listeria

Ribose-substituted aromatic amides (I) useful as antibiotics are new Ribose-substituted aromatic amides of formula (I) and their base addition salts are new. R1 = 1-8C alkyl, 2-8C alkenyl, 2-8C alkynyl, 3-8C (un)saturated cycloalkyl, 1-8C O-alkyl, 3-8C O-cycloalkyl, 2-8C O-alkenyl, 3-8C O-cycloalkenyl, 2-8C O-alkynyl, 3-8C O-cycloalkynyl (all optionally substituted by one or more halo and optionally interrupted by O, S, or N), up to 16C aryl or up to 16C aralkyl (all optionally substituted), aromatic or non-aromatic mono- or polycyclic heterocycle (optionally substituted), NH2, NHalc1, NHalc2, NHalc3 or ONHalc4; alc1, alc2, alc3, alc4 = 1-8C alkyl; R2 = H or halo; R3 = H, 1-8C alkyl or halo; R4 = NHR' or NHOR; R', R = H, 1-8C alkyl, 2-8C alkenyl, 2-8C alkynyl, 3-8C (un)saturated cycloalkyl, up to 14C aryl (optionally substituted); R5 = H or 1-8C O-alkyl; R6, R7 = alkyl or CH2-O-1-8C alkyl; or R6 + R7 = form a ring. Independent claims are also included for: (1) the preparation of (I); and (2) intermediates of formulae (II), (III), and (V). OM = a protected hydroxy group. Les composés de formule (I) (CF DESSIN DANS BOPI) R1 : alkyle, alkényle ou alkynyle, O-alkyle, O-alkényle ou O-alkynyle éventuellement substitué, éventuellement interrompu, R2 : hydrogène ou halogène,R3 : hydrogène, alkyle ou halogène,R4 : NHR' ou NHOR" R' ou R" identiques ou différents représentent hydrogène, alkyle, alkényle ou alkynyle, aryle, R5 : hydrogène ou O-alkyle,R6 : alkyle ou CH2 -O-alkyle, R7 : hydrogène ou alkyle ou bien R6 et R7 forment ensemble avec le carbone qui les porte un cycle ainsi que leurs sels d'addition avec les bases.Les composés de formule (I) présentent des propriétés antibiotiques.