PROCEDE DE PRODUCTION D'ACTIVATEUR DU PLASMINOGENE BIOLOGIQUEMENT ACTIF

ELIMINATION, DANS UN MILIEU DE CULTURE DE CELLULES HOTES RECOMBINANTES DESTINE A LA PRODUCTION D'ACTIVATEUR DU PLASMINOGENE DE TYPE TISSULAIRE HUMAIN (T-PA), DE PRATIQUEMENT TOUS LES CONSTITUANTS NEFASTES POUR LA SEPARATION ET L'ACTIVITE DUDIT T-PA. L'ELIMINATION EST EFFECTUEE AVANT C...

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1. Verfasser:	WILLIAM R. ARATHOON, STUART E. BUILDER, ANTHONY S. LUBINIECKI ET ROBERT D. VAN REIS
Format:	Patent
Sprache:	fre
Schlagworte:	APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Zusammenfassung:	ELIMINATION, DANS UN MILIEU DE CULTURE DE CELLULES HOTES RECOMBINANTES DESTINE A LA PRODUCTION D'ACTIVATEUR DU PLASMINOGENE DE TYPE TISSULAIRE HUMAIN (T-PA), DE PRATIQUEMENT TOUS LES CONSTITUANTS NEFASTES POUR LA SEPARATION ET L'ACTIVITE DUDIT T-PA. L'ELIMINATION EST EFFECTUEE AVANT CULTURE, OU APRES CULTURE PAR FILTRATION A COURANT TRANSVERSAL.APPLICATION: PRODUCTION DE T-PA BIOLOGIQUEMENT ACTIF. Biologically active human tissue-type plasminogen activator is produced in a host cell culture by removing from the medium of the culture all medium components which are detrimental to recovery and activity of the plasminogen activator. For example, cross filtration may be used to carry out medium exchange during culture, or the detrimental components may be removed prior to culturing. The cells retain their expression capability after exclusion of the harmful substances so that production of active plasminogen activator can be effected.