NOUVEAUX DERIVES DE SYNERGISTINES, LEUR PREPARATION ET LES COMPOSITIONS PHARMACEUTIQUES QUI LES CONTIENNENT

NOUVEAUX DERIVES DE SYNERGISTINES DE FORMULE GENERALE I DANS LAQUELLE Y EST HYDROGENE OU DIMETHYLAMINO ET R EST UN RADICAL QUINUCLIDINYLE-3, LEURS ISOMERES ET LEURS MELANGES, LEURS SELS AINSI QUE LEUR PREPARATION. LES PRODUITS DE FORMULE GENERALE I EVENTUELLEMENT ASSOCIES A LA PRITINAMYCINE II OU A DES DERIVES DE LA PRISTINAMYCINE II DE FORMULE GENERALE II, SONT UTILES COMME ANTIMICROBIENS.(CF DESSIN DANS BOPI) The invention provides new synergistin derivatives of formula (I) in which Y is hydrogen or dimethylamino and R is a 3- or 4-quinuclidinyl radical, the isomers thereof and their mixtures, and their salts, also the preparation thereof. These compounds may be made by reaction of the corresponding 5-methylene compounds with the appropriate mercaptoquinuclidine. The products of formula (I), optionally combined with pristinamycin IIA or a derivative of pristinamycin IIB of the formula (II) are useful as antimicrobials.