PROCEDE DE PREPARATION DES DERIVES DE LA 2-HALO-NICERGOLINE ET LEURS SELS D'ADDITION AVEC DES ACIDES AINSI QUE DES 2-HALONICERGOLINES NOUVELLES, COMPOSITIONS COMPORTANT DES 2-HALONICERGOLINES ET PROCEDE DE PREPARATION

The invention relates to a novel process for the preparation of partially new 2-halonicergoline derivatives of the formula (I), (I) wherein X stands for chlorine, bromine or iodine atom, as well as their acid addition salts. The process of the invention comprises esterifying a novel 2-halo-1-methyll...

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Bibliographische Detailangaben
1. Verfasser:	GABOR MEGYERI, TIBOR KEVE, BELA STEFKO, ERIK BOGSCH, JANOS GALAMBOS, ANNA KASSAI NEE ZIEGER, FERENC TRISCHLER, EVA PALOSI, DORA GROO, EGON KARPATI, ZSOLT SZOMBATHELYI, LASZLO SZPORNY, BELA KISS, ISTVAN LASZLOVSZKY ET ERZSEBET LAPIS
Format:	Patent
Sprache:	fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The invention relates to a novel process for the preparation of partially new 2-halonicergoline derivatives of the formula (I), (I) wherein X stands for chlorine, bromine or iodine atom, as well as their acid addition salts. The process of the invention comprises esterifying a novel 2-halo-1-methyllumilysergol of the formula (II), (II) wherein X is the same as defined above, or an acid addition salt thereof and, if desired, converting the thus-obtained 2-halonicergoline derivative of the formula (I) to an acid addition salt. The compounds of the invention improve the cognitive function of the brain and show an antihypoxic as well as a strong alpha -adrenerg blocking and calcium-antagonistic action.