NOUVEAUX DERIVES DE LA CYCLOSPORINE, LEUR PREPARATION ET LEUR UTILISATION COMME MEDICAMENTS

Cyclosporins wherein the amino acid residue at the 8-position is a (D)-acyloxy- alpha -amino acid residue, typically of formula wherein X=-MeBmt- or -dihydro-MeBmt-, Y=- alpha Abu-, -Ala-, -Thr-, -Val- or -Nva-, Z=-Val- or -Nva- and Q=R1-CO-O-CH(R2)-CH(CO-)-NH-wherein R1=H, C1-4alkyl or phenyl and R...

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Bibliographische Detailangaben
1. Verfasser:	ROLAND WENGER, RENE P. TRABER, HANS KOBEL ET HANS HOFMANN
Format:	Patent
Sprache:	fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Cyclosporins wherein the amino acid residue at the 8-position is a (D)-acyloxy- alpha -amino acid residue, typically of formula wherein X=-MeBmt- or -dihydro-MeBmt-, Y=- alpha Abu-, -Ala-, -Thr-, -Val- or -Nva-, Z=-Val- or -Nva- and Q=R1-CO-O-CH(R2)-CH(CO-)-NH-wherein R1=H, C1-4alkyl or phenyl and R2=H or CH3, possess immunosuppressive, anti-inflammatory and anti-parasitic activity.