DERIVES DE 2H-AZETO(2,1-A)-ISOQUINOLEINE, PROCEDE POUR LES PREPARER ET COMPOSITIONS PHARMACEUTIQUES LES CONTENANT

DERIVES DE 2H-AZETO(2,1-A)-ISOQUINOLEINE, PROCEDE POUR LES PREPARER ET COMPOSITIONS PHARMACEUTIQUES LES CONTENANT

The invention relates to new 2H-azeto[2,1-a]isoquinoline derivatives of formula (I) (I) wherein R1 and R2 represent hydroxyl or alkoxy having from 1 to 6 carbon atoms, R3 is hydroxyl, halogen or an group, wherein X is oxygen or sulfur, R4 is optionally substituted phenyl, and acid addition, metal an...

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Bibliographische Detailangaben
1. Verfasser: GABOR BERNATH, JENO KOBOR, ALAJOS KALMAN, PAL SOHAR, FERENC FULOP, ELEMER EZER, GYORGY HAJOS, EVA PALOSI, LASZLO DENES ET LASZLO SZPORNY
Format: Patent
Sprache:fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:The invention relates to new 2H-azeto[2,1-a]isoquinoline derivatives of formula (I) (I) wherein R1 and R2 represent hydroxyl or alkoxy having from 1 to 6 carbon atoms, R3 is hydroxyl, halogen or an group, wherein X is oxygen or sulfur, R4 is optionally substituted phenyl, and acid addition, metal and quaternary salts thereof. According to the invention the new compounds are prepared by cyclization of the corresponding compounds of formula (II), (II) wherein R1, R2 and R3 are as defined above, and Hal is halogen. Compounds of formula (I) are pharmaceutically active, in particular are potent analgesic and antipyretic agents.