NOUVELLE SOUCHE PRODUISANT DE LA CLAVINE, PROCEDE POUR SA PREPARATION, AINSI QU'UN PROCEDE MICROBIOLOGIQUE DE PRODUCTION D'ALCALOIDES DE LA CLAVINE

NOUVELLE SOUCHE PRODUISANT DE LA CLAVINE, PROCEDE POUR SA PREPARATION, AINSI QU'UN PROCEDE MICROBIOLOGIQUE DE PRODUCTION D'ALCALOIDES DE LA CLAVINE

The invention relates to a new microbiological process for the preparation of clavine alkaloids of the general formula (I), (I) wherein R stands for hydroxymethyl or methyl group, by cultivation of a Claviceps fusiformis strain in liquid submerged culture medium containing sources of carbon, nitroge...

Ausführliche Beschreibung

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Bibliographische Detailangaben
1. Verfasser: MARIA TRINN, GABRIELLA KORDIK, EVA UDVARDY NAGY, ZSUZSANNA VIDA ET ERZSEBET ZSOKA
Format: Patent
Sprache:fre
Schlagworte:
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PROCESSES USING MICROORGANISMS
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Beschreibung
Zusammenfassung:The invention relates to a new microbiological process for the preparation of clavine alkaloids of the general formula (I), (I) wherein R stands for hydroxymethyl or methyl group, by cultivation of a Claviceps fusiformis strain in liquid submerged culture medium containing sources of carbon, nitrogen, mineral salts and optionally other additives, under aerobic conditions, in which a Claviceps fusiformis variant strain deposited under No. 00211 is used as alkaloid-producing strain. The invention further relates to a biologically pure culture of the Claviceps fusiformis variant strain No. 00211 obtained in a process in which a Claviceps fusiformis strain No. 00164 is grown in a solid culture medium containing sources of carbon, nitrogen, mineral salts and agar as well as an additive promoting the formation of cytochrome P-450, followed by the selective isolation of the new strain No. 00211.