SUBSTANCES DESIGNEES PAR OF4949, LEURS DERIVES, PROCEDES POUR LEUR FABRICATION ET COMPOSITIONS PHARMACEUTIQUES A ACTIVITE D'IMMUNOMODULATION LES CONTENANT

Compounds of the formula (I): (I) and pharmaceutically acceptable salts thereof wherein R1 is hydrogen, alkyl of 1 to 10 carbon atoms or acyl of 1 to 6 carbon atoms; R2 is hydrogen or halo; R3 is hydrogen, alkyl of 1 to 6 carbon atoms or acyl of 1 to 6 carbon atoms; R4 is hydrogen or alkyl of 1 to 6 carbon atoms; R5 is hydrogen or acyl of 1 to 6 carbon atoms; X is CONH2, hydroxyalkyl of 1 to 4 carbon atoms or COOR6 wherein R6 is hydrogen or alkyl of 1 to 4 carbon atoms; and Y is CONH2, hydroxyalkyl of 1 to 4 carbon atoms or COOR7 wherein R7 is hydrogen, alkyl of 1 to 10 carbon atoms or benzyl are useful for inhibiting the activity of amino-peptidase B, exhibit immunomodulating action against living organisms and exhibit anti-inflammatory activity.