NOUVEAUX DERIVES AMINES DE L'ACIDE 4-PHENYL 4-OXO 2-BUTENOIQUES, LEUR PREPARATION, LEUR APPLICATION COMME MEDICAMENTS ET LES COMPOSITIONS LES RENFERMANT

L'INVENTION CONCERNE LES COMPOSES:(CF DESSIN DANS BOPI)OU R ET R REPRESENTENT UN HYDROGENE, UN ALKYLE 1-4C, CONH, COALC, DANS LEQUEL ALC EST UN ALKYLE 2-8C, OU SOALC DANS LEQUEL ALC EST UN ALKYLE 1-8, OU R ET R FORMENT AVEC L'AZOTE, UN HETEROCYCLE, R EST UN HYDROGENE OU UN ALKYLE 1-8C, AINSI QUE LEURS SELS ALCALINS, ALCALINO-TERREUX, D'AMMONIUM OU D'AMINES, LEUR PREPARATION, LEUR APPLICATION COMME MEDICAMENTS, NOTAMMENT ANTI-ULCEREUX, ANTISECRETOIRES GASTRIQUES ET CYTOPROTECTEURS ET LES COMPOSITIONS LES RENFERMANT. Compounds of the formula I: in which R represents a hydrogen atom or an alkyl radical containing from 1 to 8 carbon atoms and R1 and R2, which may be identical or different independently represent a hydrogen atom, an alkyl radical containing from 1 to 4 carbon atoms, a -CONH2 radical, a -CO2alk1 radical in which alk1 represents an alkyl radical containing from 2 to 8 carbon atoms, or an-SO2alk2 radical in which alk2 represents an alkyl radical containing from 1 to 8 carbon atoms, or R1 and R2 together with the nitrogen atom form a heterocycle provided that R1 and R2 are not both hydrogen, as well as the alkali metal, alkaline earth metal, ammonium or amine salts of compounds of formula I in which R represents a hydrogen atom. These compounds are useful in treating hyperchlorhydria, gastric or gastroduodenal ulcers, gastritis, hiatal hernias and gastric or gastroduodenal ailments accompanied by gastric hyperacidity. The invention includes pharmaceutical compositions comprising compounds of formula (I) as well as methods of making the compounds.