PROCEDE DE PREPARATION DE LA 2-(E)-PHEPHENYLMETHYLENE-CYCLOHEPTAN-1-ONE-(E)-OXIME

LA PRESENTE INVENTION EST RELATIVE A UN PROCEDE POUR LA PREPARATION DE 2-(E)-PHENYLMETHYLENECYCLOHEPTAN-1-ONE-(E)-OXIME REPRESENTEE PAR LA FORMULE I CI-APRES:(CF DESSIN DANS BOPI)AVEC DE L'HYDROXYLAMINE OBTENUE IN SITU A PARTIR D'UN SEL D'HYDROXYLAMINE EN PRESENCE D'UNE BASE.LE C...

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Bibliographische Detailangaben
1. Verfasser:	ZOLTAN BUDAI, TIBOR MEZEI ET LASZLO LAY
Format:	Patent
Sprache:	fre
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:	LA PRESENTE INVENTION EST RELATIVE A UN PROCEDE POUR LA PREPARATION DE 2-(E)-PHENYLMETHYLENECYCLOHEPTAN-1-ONE-(E)-OXIME REPRESENTEE PAR LA FORMULE I CI-APRES:(CF DESSIN DANS BOPI)AVEC DE L'HYDROXYLAMINE OBTENUE IN SITU A PARTIR D'UN SEL D'HYDROXYLAMINE EN PRESENCE D'UNE BASE.LE COMPOSE DE FORMULE I CONSTITUE UN INTERMEDIAIRE UTILE DANS LA SYNTHESE DE DERIVES PRESENTANT D'INTERESSANTES PROPRIETES PHARMACEUTIQUES. A process for the preparation of 2-/E/-phenylmethylenecycloheptan-1- one-/E/-oxime of the formula /I/ free of other isomers comprises reacting 2-/E/-phenylmethylenecycloheptan- 1-one of the formula /II/ with hydroxylamine obtained "in situ" from a hydroxylamine salt in the presence of a base. The reaction is carried out in water and/or in a lower, with water unrestrictedly miscible, aliphatic alcohol, and subsequently the alcohol content of the reaction medium is adjusted to 40-60%. The compound of the formula /I/ is isolated from the reaction mixture by known methods. The 2-/E/-phenylmethylenecycloheptan- 1-one-/E/-oxime of the formula /I/serves as intermediate for the synthesis of compounds possessing valuable pharmaceutical properties.