NOUVEAUX DERIVES SPIRO DU SYSTEME CYCLIQUE DE PYRAZOLO (1,5-D) (1,2,4) TRIAZINE, PROCEDE DE PREPARATION DE CES DERIVES ET MEDICAMENTS LES CONTENANT

NOUVEAUX DERIVES SPIRO DU SYSTEME CYCLIQUE DE PYRAZOLO 1,5-D 1,2,4 TRIAZINE REPRESENTES PAR LA FORMULE GENERALE I:(CF DESSIN DANS BOPI)OU LES GROUPES R ET N SONT TELS QUE DEFINIS DANS LA DESCRIPTION.ON PREPARE DE TELS DERIVES EN FAISANT REAGIR UN HYDRAZIDE D'ACIDE PYRAZOLECARBOXYLIQUE AVEC UNE CETONE CYCLIQUE, PUIS EN ALKYLANT EVENTUELLEMENT LE COMPOSE RESULTANT DE LA FORMULE I.APPLICATION A LA PREPARATION DE MEDICAMENTS PRESENTANT UNE ACTIVITE SUR LE SYSTEME NERVEUX CENTRAL. A spiro derivative of the pyrazolo [1,5-d] [1,2,4] triazine ring system of the formula I I wherein R1 and R2 represent, independently from each other, a hydrogen atom or a C1-4 alkyl group, R3 stands for a hydrogen atom, an unbranched or branched C1-4 alkyl, C2-5 alkenyl or benzyl group, R4 represents a hydrogen atom, an unbranched or branched C1-4 alkyl, C4-6 cycloalkyl, an unsubstituted or mono-halo or polyhalo benzyl group, and n is a whole number from 4 to 8, wherein R stands for an unbranched or branched C1-4 alkyl, or C4-6 cycloalkyl, C2-5 alkenyl, an unsubstituted or a monohalogeno or polyhalogenobenzyl group, and X represents a halogen or a 4-methyl-phenylsulfonyloxy group. Compounds of the formula I exhibit valuable CNS activities.