NOUVELLES IMINES CYCLIQUES, LEUR PREPARATION ET COMPOSITIONS PHARMACEUTIQUES CONTENANT CELLES-CI

LA PRESENTE INVENTION EST RELATIVE A DE NOUVELLES IMINES CYCLIQUES.CES IMINES SONT REPRESENTEES PAR LA FORMULE GENERALE I CI-APRES DANS LAQUELLE A REPRESENTE UN GROUPE CARBONYLE OU HYDROXYMETHYLENE, B EST UN ATOME D'OXYGENE OU UN GROUPE IMINO-, R EST UN ATOME D'HYDROGENE OU UN RADICAL ALKYLE INFERIEUR, X ET X PEUVENT ETRE IDENTIQUES OU DIFFERENTS ET REPRESENTENT UN ATOME D'HYDROGENE OU D'HALOGENE, UN GROUPE ALKYLE OU ALCOXY-INFERIEUR, AMINO- OU NITRO-, N EST EGAL A 6 OU 7, ET M EST EGAL A 0 OU 1.MEDICAMENTS POUR LES MALADIES CARDIO-VASCULAIRES.(CF DESSIN DANS BOPI) The invention relates to new cyclic imines of the general formula (I), (I) wherein A represents carbonyl or hydroxymethylene, B is oxygen or imino, R stands for hydrogen or lower alkyl, X1 and X2 may be the same or different and represent hydrogen, halogen, lower alkyl or alkoxy, amino or nitro, n is 6 or 7, and m is 0 or 1, and pharmaceutically acceptable acid addition salts and quaternary salts thereof. The invention relates further to a process for the preparation of said compounds, to pharmaceutical compositions containing said compounds as the active ingredient and to a process for the preparation of said pharmaceutical compositions. The cyclic imine derivatives of the invention possess valuable antiarrhythmic properties and can be used to advantage in the treatment of cardiovascular diseases.