DERIVES DE CARBOXIMIDE, PROCEDES POUR LEUR PREPARATION ET MEDICAMENT LES CONTENANT

L'INVENTION CONCERNE DES DERIVES DE CARBOXIMIDE DE FORMULE:(CF DESSIN DANS BOPI)OU X REPRESENTE UN GROUPE DE FORMULE:(CF DESSIN DANS BOPI)Z REPRESENTE L'HYDROGENE OU UN GROUPE -C-R OU R REPRESENTE UN GROUPE ALKYLE, ARALKYLE, ARYLE, CYCLOALKYLE, ALCENYLE, ARYLALCENYLE, PYRIDYLE OU AMINO SUBSTITUE; Y REPRESENTE UN GROUPE ALKYLE, ARALKYLE, ARYLE, PYRIDYLE SUBSTITUE OU NON-SUBSTITUE, PYRIMIDYLE SUBSTITUE OU NON-SUBSTITUE, OU BENZOTHIAZOLYLE; ET M EST 2 OU 3 ET LEURS SELS PHARMACEUTIQUEMENT ACCEPTABLES. LES DERIVES ET LEURS SELS POSSEDENT UNE ACTIVITE HYPOGLYCEMIQUE ET SONT UTILES POUR LE TRAITEMENT DU DIABETE. The carboximide derivatives of the formula: and pharmaceutically acceptable salts thereof; wherein X represents a group of the formula: +TR Z represents a hydrogen atom or a group of the formula: wherein R represents an alkyl group, an aralkyl group, an aryl group, a cycloalkyl group, an alkenyl group, an arylalkenyl group, a pyridyl group or a substituted amino group; Y represents an alkyl group, an aralkyl group, an aryl group, a substituted or unsubstituted pyridyl group, a substituted or unsubstituted pyrimidyl group or a benzothiazolyl group; and m represents an integer of 2 or 3 and processes for the production thereof. The derivatives and their salts possess hypoglycemic activity and are useful for treating diabetes.