Antibacterial antibiotic xanthothricin microbiological prodn. - by cultivation of Streptomyces brunnei sub:species xanthothricini

Antibacterial antibiotic xanthothricin microbiological prodn. - by cultivation of Streptomyces brunnei sub:species xanthothricini

In a new process for the prodn. of xanthothricin by cultivation of a microorganism on a nutrient medium contg. C sources, N sources and mineral salts and subsequent isolation of the end prod. from the culture fluid, Streptomyces brunneus subspecies xanthothricini is used as the microorganism. Xantho...

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1. Verfasser: VALENTINA ANDREEVNA SEMENOVA, MARIA MIRONOVNA TAIG, NADEZHDA KONSTANTINOVA SOLOVIEVA, MIKHAIL NIKOLAEVICH KOKOSOV, STANISLAV EMELYANOVICH ESIPOV, LJUDMILA, GEORGIEVNA BELYAKOVA, LILIA ALEXANDROVNA SABUROVA, TAMARA IVANOVNA GOROKHOVA, TALYANA GEORGIEVNA TERENTIEVA ET SERGEI MIKHAILOVICH NAVASHIN
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:In a new process for the prodn. of xanthothricin by cultivation of a microorganism on a nutrient medium contg. C sources, N sources and mineral salts and subsequent isolation of the end prod. from the culture fluid, Streptomyces brunneus subspecies xanthothricini is used as the microorganism. Xanthothricin (synonym toxoflavin) is a known antibiotic with antibacterial activity. Unlike known xanthothricin producing organisms, Streptomyces brunneus subspecies, xanthothricini has a high capacity for producing xanthothricini. La présente invention concerne un procédé de préparation de xanthothricine. Suivant l'invention le procédé de préparation de xanthothricine consiste à cultiver sur un milieu nutritif contenant des sources de carbone, d'azote et des sels minéraux un microorganisme tel que Strepromyces brunneus Subspecies xanthothricini RIA-1568 dans les conditions aérobies à une température de 26 à 29 degrés C. L'invention trouvera des applications dans l'industrie des produits pharmaceutiques.