EPOXYDES DE TRICHOTHECENE EXTRAITS DE SUBSTANCES VEGETALES ET LEURS UTILISATIONS THERAPEUTIQUES

EPOXYDES MACROCYCLIQUES EXTRAITS D'UN VEGETAL, LEUR MODE D'ISOLEMENT ET LEURS UTILISATIONS THERAPEUTIQUES.CES COMPOSES SE CARACTERISENT PAR UN SYSTEME CYCLIQUE CENTRAL DE 12, 13-EPOXY-TRICHOTHECENE RELIE AUX DEUX EXTREMITES D'UNE CHAINE DE MACROLIDE DIENIQUE, PAR EXEMPLE SELON LA FORMULE:(CF DESSIN DANS BOPI)(CF DESSIN DANS BOPI)DANS LAQUELLE:(CF DESSIN DANS BOPI)CES EPOXYDES ONT DES PROPRIETES ANTI-LEUCEMIQUES EXPLOITABLES EN THERAPEUTIQUE. There are provided novel anti-leukemic epoxides which are isolated from Baccharis megapotamica. The novel compounds are characterized by a 12,13-epoxytrichothecene central ring system which is spanned by a dienic macrolide ester side chain. The active compounds are characterized by the presence of an oxygen atom in the A-ring which takes the form of either a beta hydroxy group in the 8 position together with an unsaturated bond at the 9: 10 position or, alternatively, an epoxide group lying between the 9 and 10 position. Compounds devoid of either of these groups show no anti-leukemic activity.