Recovering the antimycotic mycoheptin from mycelia - of Streptoverticillium mycoheptinicum by extraction with aq. isopropanol then purificn

Recovering the antimycotic mycoheptin from mycelia - of Streptoverticillium mycoheptinicum by extraction with aq. isopropanol then purificn

Process comprises first extracting the mycelium with 65-80% aq. isopropanol contg. 1-10wt.% CaCl2 and 10-15wt.% CH2CO2. (I) is then pptd., washed with aq. isopropanol, taken up in DMF and pptd. with water. The second ppte. is then treated with 20-50% aq. n-propanol contg. 0.2-0.5wt.% Na hexametaphos...

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Bibliographische Detailangaben
1. Verfasser: E. D. ETINGOV, A. P. BASHKOVICH, V. O. KULBAKH, V. Y. RAIGORODSKAYA, I. V. POPOVA, L. E. ALEXEEVA, V. S. NYN ET N. D. LOKHINA
Format: Patent
Sprache:eng ; fre
Schlagworte:
BEER
BIOCHEMISTRY
CHEMISTRY
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
METALLURGY
MICROBIOLOGY
MUTATION OR GENETIC ENGINEERING
SPIRITS
VINEGAR
WINE
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Beschreibung
Zusammenfassung:Process comprises first extracting the mycelium with 65-80% aq. isopropanol contg. 1-10wt.% CaCl2 and 10-15wt.% CH2CO2. (I) is then pptd., washed with aq. isopropanol, taken up in DMF and pptd. with water. The second ppte. is then treated with 20-50% aq. n-propanol contg. 0.2-0.5wt.% Na hexametaphosphate (II). Pref. extraction soln. contains 2wt.% CaCl2 and 10wt.% CH2Cl2 and the second ppte. wash soln. is pref. 40% n-propanol contg. 0.5% (II). (I) is used to treat mycotic diseases such as coccidiosis, histoplasmosis or candidiasis. The extraction efficiency is high and (I) is obtd. in improved yield (33% of total activity in the mycelium) and purity.