4-Oxa or thia spiro (4,5) decane derivs - are CNS stimulants and psychotonics

4-Oxa or thia spiro (4,5) decane derivs - are CNS stimulants and psychotonics

Title cpds. of formula (I): (where A = O or S, R1,R2 independently = H, lower alkyl or aryl e.g. phenyl and X = H, halo (e.g. Cl or F) or lower alkyl, specif. where a) A = O, R1, R2 = CH3 and X = 4-F, 4-CH3, 3-CH3, 4-Cl and 3-Cl, b) A = O, R1 = CH3, R2 = H and X = 3-CH3, 3-Cl, 4-CH3, 4-F, 4-Cl and H...

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Bibliographische Detailangaben
1. Verfasser: ROLAND YVES MAUVERNAY, NORBERT BUSCH, JACQUES MOLEYRE, JACQUES SIMOND ET ANDRE MONTEIL
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:Title cpds. of formula (I): (where A = O or S, R1,R2 independently = H, lower alkyl or aryl e.g. phenyl and X = H, halo (e.g. Cl or F) or lower alkyl, specif. where a) A = O, R1, R2 = CH3 and X = 4-F, 4-CH3, 3-CH3, 4-Cl and 3-Cl, b) A = O, R1 = CH3, R2 = H and X = 3-CH3, 3-Cl, 4-CH3, 4-F, 4-Cl and H, c) A = O, R1 = phenyl, R2 = H, and X = 3-CH3, 3-Cl or 4-Cl d) A = S, R1 = CH3, R2 = H and X=4-CH3, H, 2-CH3, 3-CH3, 3-Cl and 4-Cl) are CNS stimulants and psychotonics administered e.g. in doses of 25 mg. (I) have low toxicity cf. amphetamines.