Analgesic indole (1)-acetic acids and esters - with (6)-methoxy, (2)-methyl and (3)-benzoyl substituents

Analgesic indole (1)-acetic acids and esters - with (6)-methoxy, (2)-methyl and (3)-benzoyl substituents

Indole-acetic acid derivs. of formula (I) are new together with their acid addn salts. (where R1 is CF3.S-; R2 is H or the gp. (I) are almost free of antiinflammatory activity. Used for human and veterinary medicine. A typical cpd. 2- 6-methoxy-2-methyl-3-(3-trifluoromethylthiobenzoyl)-1-indole acet...

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1. Verfasser: PHILIPPE MICHEL JACQUES MANOURY, JEAN LOUIS CHRISTIAN BINET, BOGDAN ILIESCO-BRANCENI, MONIQUE PROUTEAU, HENRY NAJER ET DON PIERRE RENE LUCIEN GIUDICELLI
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:Indole-acetic acid derivs. of formula (I) are new together with their acid addn salts. (where R1 is CF3.S-; R2 is H or the gp. (I) are almost free of antiinflammatory activity. Used for human and veterinary medicine. A typical cpd. 2- 6-methoxy-2-methyl-3-(3-trifluoromethylthiobenzoyl)-1-indole acetic acid is prepd. by treating the analogue with unsubstd. N atom with an alkyl haloacetate and hydrolysing the ester.