Kemiallisia yhdisteitä

Kemiallisia yhdisteitä

PCT No. PCT/EP93/01520 Sec. 371 Date Nov. 25, 1994 Sec. 102(e) Date Nov. 25, 1994 PCT Filed Jun. 14, 1993 PCT Pub. No. WO93/25548 PCT Pub. Date Dec. 23, 1993This invention relates to heterocyclic compounds which are inhibitors of the enzyme aromatase, to processes for their preparation, to pharmaceu...

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Bibliographische Detailangaben
Hauptverfasser: MERRITT, ANDREW THOMAS, CHERRY, PETER CLIVE, FOXTON, MICHAEL WALTER
Format: Patent
Sprache:fin ; swe
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:PCT No. PCT/EP93/01520 Sec. 371 Date Nov. 25, 1994 Sec. 102(e) Date Nov. 25, 1994 PCT Filed Jun. 14, 1993 PCT Pub. No. WO93/25548 PCT Pub. Date Dec. 23, 1993This invention relates to heterocyclic compounds which are inhibitors of the enzyme aromatase, to processes for their preparation, to pharmaceutical compositions containing them and to their use in medicine. Particular compounds of the invention are compounds of formula (I) (I) wherein R1 represents a cyano or nitro group; R2 represents hydrogen or one or more halogen atoms; R3 represents a C1-6alkyl group and R4 represents hydrogen or a C1-6alkyl group or R3 and R4 together represent a C3-6cycloalkyl group; and R5 represents hydrogen or one or more halogen atoms or C1-6alkoxy groups and pharmaceutically acceptable salts and solvates thereof.