Monoklonaalisia vasta-aineita syklosporiineille

Immunogenic conjugates comprising a carrier coupled to a cyclosporin having an activate coupling group, e.g. activated carboxy group, e.g. (i) [(O-succinimidooxysuccinyl)-Thr] -Cyclosporine and (ii) [(N- epsilon -succinimidooxysuccinyl)-(D)Lys] -Cyclosporine. The subject conjugates are useful for th...

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Bibliographische Detailangaben
Hauptverfasser:	WENGER, ROLAND, BALL, PHILLIP E, ROSENTHALER, JOACHIM, SCHREIER, MAX H, QUESNIAUX, VAL~RIE
Format:	Patent
Sprache:	fin ; swe
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	Immunogenic conjugates comprising a carrier coupled to a cyclosporin having an activate coupling group, e.g. activated carboxy group, e.g. (i) [(O-succinimidooxysuccinyl)-Thr] -Cyclosporine and (ii) [(N- epsilon -succinimidooxysuccinyl)-(D)Lys] -Cyclosporine. The subject conjugates are useful for the generation of monoclonal antibodies capable of distinguishing between cyclosporins, e.g. Cyclosporine, and metabolites, e.g. Cyclosporins 17 and 18.