Menetelmä nukleosidijohdannaisten valmistamiseksi

Menetelmä nukleosidijohdannaisten valmistamiseksi

The invention concerns a process for the preparation of nucleoside derivatives espcecially of AZT. As the starting material a 2,3'-anhydroderivative of the said nucleoside is used, which in its 5'-position carries a largish protecting group, which is stable under weakly alkaline, but which...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: KORPELA, TIMO, AZHAYEV, ALEX V
Format: Patent
Sprache:fin ; swe
Schlagworte:
CHEMISTRY
DERIVATIVES THEREOF
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
SUGARS
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Beschreibung
Zusammenfassung:The invention concerns a process for the preparation of nucleoside derivatives espcecially of AZT. As the starting material a 2,3'-anhydroderivative of the said nucleoside is used, which in its 5'-position carries a largish protecting group, which is stable under weakly alkaline, but which is split off in strongly alkaline conditions, especially pivaloyl, or adamantoyl. This compound is reacted with sodium or potassium azide and lithium halide in the presence of a buffering salt, whereafter the 5'-protecting group is split off from the obtained 3'-azido-nucleoside by treating with a base.