DERIVAT AV TVAOVAERD PLATINA MED POLYMETYLSILOXAN, FOERFARANDE FOER FRAMSTAELLNING AV DESSA DERIVAT OCH PAO DERIVATEN BASERAT LAEKEMEDELSPREPARAT MED ANTITUMOERVERKAN

Derivatives of platinum (P) with methyl silicone are xerogels - a product of reaction between a complex compound of platinum (P) in an aqueous solution of sodium chloride, on the one hand, and a hydrogel of methyl silicone, on the other hand, at a molar ratio of Pt:Si:NaCl equal to 1-3:50:23-69, sai...

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Hauptverfasser:	SAMODUMOVA, INNA MIKHAILOVNA, SHALIMOV, SERGEI ALEXANDROVICH, TROKHIMENKO, ELENA PETROVNA, BUDARIN, LEV IVANOVICH, MAIDANEVICH, NADEZHDA NIKOLAEVNA, GIRIN, VITALY NIKOLAEVICH, VOLCHENSKOVA, ILIMA ILIODOROVNA, KEISEVICH, LJUDVIG VLADISLAVOVICH
Format:	Patent
Sprache:	fin
Schlagworte:	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY COMPOSITIONS BASED THEREON HUMAN NECESSITIES HYGIENE MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONSONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY ORGANIC MACROMOLECULAR COMPOUNDS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS THEIR PREPARATION OR CHEMICAL WORKING-UP
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Zusammenfassung:	Derivatives of platinum (P) with methyl silicone are xerogels - a product of reaction between a complex compound of platinum (P) in an aqueous solution of sodium chloride, on the one hand, and a hydrogel of methyl silicone, on the other hand, at a molar ratio of Pt:Si:NaCl equal to 1-3:50:23-69, said product being a three-dimensional cross-linked polymer of globular structure with a globule diameter of 4.0-7.0 nm and a specific surface of 80-200 m /g and having a link of the following general formula: -{[PtCl(NH3)2O0,5]n(NaCl)5n(CH3SiO1,5)50(Na2O)10(H2O)20}-, where n = 1 to 3. A method of obtaining said compounds consists in reacting the complex compound of platinum (P) in the aqueous solution of sodium chloride with the hydrogel of methyl silicone at a molar ratio of Pt:Si:NaCl equal to 1-3:50:23-69 with subsequent extraction of the desired product. The claimed compounds have antitumoral activity. The claimed means of antitumoral action consists of an active agent - the claimed compound having a link of the following formula: -{[PtCl(NH3)2O0,5]2(NaCl)10(CH3SiO1,5)50(Na2O)10(H2O)20}-.