FOERFARANDE FOER FRAMSTAELLNING AV 5,8,13, 14-TETRAHYDROBENZ/5,6/ISOINDOLO/2,1-B/ISOKINOLIN-8,13-DIONDERIVAT

FOERFARANDE FOER FRAMSTAELLNING AV 5,8,13, 14-TETRAHYDROBENZ/5,6/ISOINDOLO/2,1-B/ISOKINOLIN-8,13-DIONDERIVAT

A process is described for the preparation of compounds of formula (1) [where OR is hydroxyl, protected hydroxyl or OP(O)(OCH2Ph)(OR ) (where Ph is phenyl and OR is hydroxyl or protected hydroxyl)] and salts thereof, which comprises reacting a compound of formula (2) with a compound of formula (3) (...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: PHILLIPS, GORDON HANLEY, COWLEY, BRIAN RICHARD
Format: Patent
Sprache:fin
Schlagworte:
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:A process is described for the preparation of compounds of formula (1) [where OR is hydroxyl, protected hydroxyl or OP(O)(OCH2Ph)(OR ) (where Ph is phenyl and OR is hydroxyl or protected hydroxyl)] and salts thereof, which comprises reacting a compound of formula (2) with a compound of formula (3) (where OR is as defined above and one of X and X is a leaving group and the other is a hydrogen atom) or a salt thereof, followed, if desired, by removal of the hydroxyl protecting group when present and/or by salt formation. The compounds of formula (1) are either anticancer agents or intermediates useful in the synthesis of anticancer agents.